Cat. No.: IBDAK-620453
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| Sample Type | Cell culture supernatant, Serum, Plasma |
| Detection Method | Colorimetric |
| Assay Type | Sandwich (quantitative) |
| Assay Duration | Multiple steps standard assay |
| Product Type | Cell Type Markers |
| Sensitivity | 0.26 ng/ml |
| Range | 0.234 ng/ml - 15 ng/ml |
| Species Reactivity | Reacts with: Mouse |
| Platform | Pre-coated microplate (12 x 8 well strips) |
Target
| Function | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. |
| Sequence Similarities | Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. Contains 2 fibronectin type-III domains. Contains 2 tyrosine-protein phosphatase domains. |
| Cellular Localization | Membrane. Membrane raft. Colocalized with DPP4 in membrane rafts. |
| Domain | The first PTPase domain interacts with SKAP1. |
Storage & Handling
| Storage | Store at +4°C. |
| Storage Buffer | Constituent: 100% PBS |