Mouse CD44 ELISA Kit

Overview

Sample Type	Cell culture supernatant, Serum, Cell Lysate, Hep Plasma, EDTA Plasma
Detection Method	Colorimetric
Assay Type	Sandwich (quantitative)
Assay Time	3 h 30 min
Assay Duration	Multiple steps standard assay
Product Type	Cell Type Markers
Sensitivity	< 10 pg/ml
Range	312 pg/ml - 20000 pg/ml
Species Reactivity	Reacts with: Mouse
Platform	Pre-coated microplate (12 x 8 well strips)

Target

Function	Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
Tissue Specificity	Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.
Sequence Similarities	Contains 1 Link domain.
Cellular Localization	Membrane.
Domain	The lectin-like LINK domain is responsible for hyaluronan binding.

Storage & Handling

Storage

Store at -20°C. Please refer to protocols.