Cat. No.: IBDAK-620465
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| Assay Type | ELISA set |
| Product Type | Cell Type Markers |
| Range | 62.5 pg/ml - 4000 pg/ml |
| Species Reactivity | Reacts with: Mouse |
| Platform | Reagents |
| Application | Sandwich ELISA |
Properties
| Carrier Free | Yes |
Target
| Function | Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules. |
| Tissue Specificity | Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages. |
| Sequence Similarities | Contains 11 LRR (leucine-rich) repeats. |
| Cellular Localization | Cell membrane. |
Storage & Handling
| Storage | Store at +4°C. |
| Storage Buffer | Constituent: 100% PBS |