Methylnissolin

Cat. No.: IBDI-430408

Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade.

Product Details

Target	PDGFR | ERK
Molecular Weight	300.31
Appearance	Solid
Synonyms	Astrapterocarpan
SMILES	COC1=C2O[[email protected]]3([H])[[email protected]](COC4=CC(O)=CC=C34)([H])C2=CC=C1OC
Structure Classification	Flavonoids>Other Flavonoids Phenols>Monophenols
Purity	99.64%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.