Cat. No.: IBDAK-620533
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| Sample Type | Cell Lysate, Tissue Homogenate |
| Detection Method | Colorimetric |
| Assay Type | Semi-quantitative |
| Assay Time | 1 h 30 min |
| Assay Duration | One step assay |
| Product Type | TLR Signaling |
| Sensitivity | 0.5 ng/ml |
| Range | 1 ng/ml - 100 ng/ml |
| Species Reactivity | Reacts with: Mouse, Human Predicted to work with: Rat |
| Platform | Microplate |
Target
| Function | Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. |
| Sequence Similarities | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain. |
| Domain | The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. |
Storage & Handling
| Storage | Store at +4°C. Please refer to protocols. |