Human ULBP2 ELISA Kit

Overview

Sample Type	Cell culture supernatant, Serum, Hep Plasma, EDTA Plasma
Detection Method	Colorimetric
Assay Type	Sandwich (quantitative)
Assay Time	1 h 30 min
Assay Duration	One step assay
Product Type	TLR Signaling
Sensitivity	6.18 pg/ml
Range	25 pg/ml - 1600 pg/ml
Species Reactivity	Reacts with: Human
Platform	Pre-coated microplate (12 x 8 well strips)

Target

Function	Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
Tissue Specificity	Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.
Sequence Similarities	Belongs to the MHC class I family.
Cellular Localization	Cell membrane. Secreted.

Storage & Handling

Storage

Store at +4°C. Please refer to protocols.