Cat. No.: IBDAK-620621
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| Sample Type | Cell culture supernatant, Serum, Cell culture media, Hep Plasma, EDTA Plasma, Cit plasma |
| Detection Method | Colorimetric |
| Assay Type | Sandwich (quantitative) |
| Assay Time | 1 h 30 min |
| Assay Duration | One step assay |
| Product Type | TLR Signaling |
| Sensitivity | 22.06 pg/ml |
| Range | 109.38 pg/ml - 7000 pg/ml |
| Species Reactivity | Reacts with: Human Does not react with: Cow |
| Platform | Pre-coated microplate (12 x 8 well strips) |
Target
| Function | Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. |
| Tissue Specificity | Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. |
| Sequence Similarities | Belongs to the interleukin-1 receptor family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 TIR domain. |
| Cellular Localization | Secreted and Cell membrane. |
Storage & Handling
| Storage | Store at -20°C. Please refer to protocols. |