Cat. No.: IBDAK-620642
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| Sample Type | Cell culture supernatant, Serum, Plasma |
| Detection Method | Colorimetric |
| Assay Type | Sandwich (quantitative) |
| Assay Duration | Multiple steps standard assay |
| Product Type | Secreted Molecules |
| Sensitivity | 0.12 ng/ml |
| Range | 0.12 ng/ml - 25 ng/ml |
| Species Reactivity | Reacts with: Human |
| Platform | Microplate |
Target
| Function | Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. |
| Tissue Specificity | Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis. |
| Sequence Similarities | Contains 1 C-type lectin domain. |
| Cellular Localization | Secreted. Found in the apical region of pancreatic acinar cells. |
| Domain | The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity. |
Storage & Handling
| Storage | Store at -20°C. Please refer to protocols. |