Cat. No.: IBDAK-620659
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Online InquiryOverview
| Product Type | Macrophage / Inflamm. |
Target
| Function | Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. |
| Tissue Specificity | Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium. |
| Sequence Similarities | Contains 1 C2 domain. Contains 1 PLA2c domain. |
| Cellular Localization | Cytoplasm. Cytoplasmic vesicle. Translocates to membrane vesicles in a calcium-dependent fashion. |
| Domain | The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+). |
Storage & Handling
| Storage | Store at -80°C. Please refer to protocols. |