Human C5 Antibody Pair - BSA and Azide free

Overview

Assay Type	ELISA set
Product Type	Macrophage / Inflamm.
Range	31 pg/ml - 2000 pg/ml
Species Reactivity	Reacts with: Human
Platform	Reagents
Application	Sandwich ELISA

Properties

Carrier Free

Yes

Target

Function	Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).
Sequence Similarities	Contains 1 anaphylatoxin-like domain. Contains 1 NTR domain.
Cellular Localization	Secreted.

Storage & Handling

Storage	Store at +4°C.
Storage Buffer	pH: 7.2 Constituent: 100% PBS