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Extensive Colitis Research Services

Extensive colitis is a form of ulcerative colitis that affects the entire large intestine or bowel. Inflammation starts at rectum and goes beyond splenic flexure. It is a type of inflammatory bowel disease (IBD) with wide ranging symptoms, such as bloody diarrhea, pain in your belly, lack of appetite, weight loss, fever, and cramps. It is a chronic condition, meaning it develops over a long period, and there is currently no known cure.

Customized Studies for Extensive Colitis

Ace Therapeutics provides customized preclinical research for extensive colitis, supporting the advancement of your program. Leveraging our translational research expertise, broad-range of assays, animal models, and customized approach, we provide superior preclinical research support for your program to address the unique challenges posed by these conditions.

To meet the needs of your specific extensive colitis drug discovery project, we have the flexibility and expertise to develop custom in vivo models.

• Disease modeling. We select specific animal models, such as DSS-induced, TNBS-induced or IL-10-deficient mice, to replicate the clinical symptoms and pathological features of extensive colitis.
• Drug screening and optimization. We use the established animal models to evaluate the in vivo activity of the drug candidates, including efficacy, safety, pharmacokinetics, and other aspects of the study.
• Mechanism of action studies. We help clients to explore the targets of drug candidates and the signaling pathways they regulate, and to elucidate the molecular mechanisms of their therapeutic effects. We provide cellular and molecular biology techniques for in-depth mechanism of action analysis.
• Safety evaluation. We evaluate the absorption, distribution, metabolism and excretion (ADME) characteristics of drug candidates in vivo, as well as their toxicological profiles.

Type of Drugs We Can Develop for Extensive Colitis

• Biologics
• Immunomodulators
• Systemic steroids

Ace Therapeutics actively collaborates with researchers and pharmaceutical companies committed to extensive colitis research. Our extensive experience and specialized models enable us to provide a comprehensive and tailored approach to the preclinical development of your novel extensive colitis therapies. Contact us today to learn more!