Destruxin B

Cat. No.: IBDI-430227

Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells. Destruxin B significantly activates caspase-3 and reduces tumor cell proliferation through caspase-mediated apoptosis, not only in vitro but also in vivo.

Product Details

Target	Bcl-2 Family | Caspase | Apoptosis
Molecular Weight	621.81
Appearance	Solid
SMILES	O=C(N[[email protected]]([[email protected]@H](C)CC)(C)C(N(C)[[email protected]@H](C(C)C)C(N(C)[[email protected]@H](C)C(NCC1)=O)=O)=O)[[email protected]@](CCC2)(C)N2C([[email protected]@H](CC(C)C)OC1=O)=O
Structure Classification	Cyclopeptides
Purity	99.35%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.