Dehydroaltenusin

Cat. No.: IBDI-430703

Dehydroaltenusin is a small molecule selective inhibitor of eukaryotic DNA polymerase α, a type of antibiotic produced by a fungus with an IC50 value of 0.68 μM. The inhibitory mode of action of dehydroaltenusin against mammalian pol α activity is competitive with respect to the DNA template primer (Ki=0.23 µM) and non-competitive with respect to the 2'-deoxyribonucleoside 5'-triphosphate substrate (Ki=0.18 µM). Dehydroaltenusin arrests the cancer cell cycle at the S-phase and triggers apoptosis. Dehydroaltenusin possesses anti-tumor activity against human adenocarcinoma tumor in vivo.

Product Details

Target	Apoptosis | DNA/RNA Synthesis | Antibiotic
Molecular Weight	288.25
SMILES	O=C(C(O)=C1)C=C(C2=CC(OC)=CC(O)=C23)[[email protected]@]1(C)OC3=O
Structure Classification	Phenols>Monophenols Antibiotics>Other Antibiotics

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.