Daphnetin

Cat. No.: IBDI-430838

Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1ß, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research.

Product Details

Target	EGFR | PKA | PKC | Autophagy | Apoptosis | AMPK | Akt | mTOR | Reactive Oxygen Species | Caspase | Bcl-2 Family | PARP | PaRasite
Molecular Weight	178.14
Appearance	Solid
Synonyms	7,8-Dihydroxycoumarin
SMILES	O=C1C=CC2=CC=C(O)C(O)=C2O1
Structure Classification	Phenylpropanoids>Coumarins Phenols>Polyphenols
Purity	99.86%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.