Cytochalasin D

Cat. No.: IBDI-430539

Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap.

Product Details

Target	Arp2/3 Complex | Antibiotic | YAP
Molecular Weight	507.62
Appearance	Solid
Synonyms	Zygosporin A, NSC 209835
SMILES	C=C1[[email protected]@H](O)[[email protected]@]2([H])[[email protected]@]3([[email protected]](OC(C)=O)/C=C/[[email protected]](O)(C)C([[email protected]@H](C)C/C=C/2)=O)[[email protected]@]([[email protected]](CC4=CC=CC=C4)NC3=O)([H])[[email protected]@H]1C
Structure Classification	Others
Purity	99.82%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.