Customized Chemical-Induced IBD Models

Animal models of IBD are essential for understanding of the pathogenesis of Crohn's disease and ulcerative colitis. Various animal models have been developed to study IBD. Among these, the widely used models include chemical-induced colitis model that is sub-categorized into dextran sodium sulphate (DSS)-induced colitis, trinitrobenzene sulfonic acid (TNBS)-induced colitis, oxazolone-induced colitis, acetic acid-induced colitis, nonsteroidal anti-inflammatory drugs (NSAIDs)-induced colitis, carrageenan-induced colitis model, peptidoglycan-polysaccharide (PGPS)-induced colitis. They are reproducible and easy to develop, and all can be used to study intestinal fibrosis and inflammation-related carcinogenesis.

Fig. 1. Chemical-induced IBD models are widely used to study the pathogenesis and complexity of human IBD. Fig. 1. The five experimental models of inflammation are grouped here in relation to their varying inducing conditions. (Kiesler et al., 2015)

Our Chemical-Induced IBD Models

Ace Therapeutics is a global leading preclinical contract research provider focused on providing preclinical IBD drug development services. We offer a wide range of customized chemical-induced IBD models to help clients understand the histopathological and morphological changes in the gut, develop novel therapeutic agents, and dissect the possible mechanisms of action of specific drugs.

The different models in this category have their own specific uses due to the different methods of disease induction. Our experts can guide you in selecting the appropriate models depending on your therapeutic target, resulting in data that accurately represents human IBD.

Chemical-Induced IBD Models	Features
DSS-Induced Colitis Models	Most convenient and reproducible model of colitis. Acute and chronic colitis could be induced by adjusting dosage and cycles of administration. Can be used to study IBD mechanisms and develop appropriate palliative and therapeutic strategies.
TNBS/DNBS Colitis Models	T-cell-mediated transmural colitis can be induced by haptenization in forms of acute and chronic inflammation resembling human IBD. The susceptibility against TNBS/DNBS induced colitis depends on types of transgenic mice. Can be used to identify and characterize drugs candidates and test their effects on different IBD or other forms of intestinal mucosal inflammation.
Poly I:C-Induced Intestinal Inflammation Models	Induce intestinal inflammation by a single intraperitoneal (IP) injection of poly I:C in mice. Can be used to investigate the pathogenesis of IBD and evaluate the therapeutic potential of new drugs.
Oxazolone-Induced Colitis Models	Intrarectal administration cause severe colitis in distal half of the colon which mimics human UC. Can be used to study the pathomechanisms of UC and evaluate drugs that target Th2-mediated mechanisms.
Acetic Acid-Induced Colitis Models	Primarily acute colitis is induced by chemical injury and chronic colitis could be generated in dose and duration dependent manner. Mimicking some features of UC with involvement of distal colon. Can be used to understand the pathophysiology of IBD and preclinical screening of therapeutic compounds for novel treatments.
Indomethacin-Induced Colitis Models	Induce different acute and chronic phases of IBD involving the small and large intestine. Indomethacin injections can cause clinical symptoms and mechanisms similar to CD. Determine the role of various factors involved in the pathogenesis of intestinal inflammation. Provide a reliable, non-invasive model for drug screening.

Ace Therapeutics provides a variety of chemical-induced IBD models for biotech and pharmaceutical companies. We also provide a one-stop solution for your project, from colitis model construction to drug efficacy evaluation. Whatever step you take, we are your trusted partner! Please contact us to discuss your needs.

Reference

Kiesler, P., et al. (2015). Experimental models of inflammatory bowel diseases. Cellular and molecular gastroenterology and hepatology, 1(2), 154-170.

! For research use only, not intended for any clinical use.