Cat. No.: IBDA-434095
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Online InquiryTarget Information
| Target Name | CCL4/MIP-1 Beta |
| Uniprot ID | P13236 |
| Cellular Localization | Secreted. |
| Immunogen | Recombinant full length protein corresponding to Mouse CCL4/MIP-1 beta aa 1 to the C-terminus. |
| Function | Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. |
Product Details
| Description | Rabbit polyclonal antibody to CCL4/MIP-1 beta. |
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Purity | Caprylic acid and ammonium sulfate precipitation |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Recombinant full length protein corresponding to Mouse CCL4/MIP-1 beta aa 1 to the C-terminus. |
| Positive Control | IHC-P: Human kidney tissue. |
| Application | IHC-P |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.20 Preservative: 0.0975% Sodium Azide Constituent: 0.58% Sodium Chloride |
| Handling | Avoid freeze-thaw cycles. |