Calcimycin hemicalcium salt

Cat. No.: IBDI-430225

Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca 2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis.

Product Details

Target	Bacterial | Fungal | Apoptosis | Autophagy | Antibiotic
Molecular Weight	1085.30
Synonyms	A-23187 hemicalcium salt, Antibiotic A-23187 hemicalcium salt
SMILES	CNC1=CC=C2OC(C[[email protected]@H]3[[email protected]@H](CC[[email protected]@]4(O3)[[email protected]@H](C[[email protected]]([[email protected]](O4)[[email protected]@H](C(C5=CC=CN5)=O)C)C)C)C)=NC2=C1C([O-][Ca+2][O-]C(C6=C7N=C(C[[email protected]]8O[[email protected]]9(O[[email protected]]([[email protected]](C)C(C%10=CC=CN%10)=O)[[email protected]](C)C[[email protected]]9C)CC[[email protected]]8C)OC7=CC=C6NC)=O)=O
Structure Classification	Antibiotics>Polyether Antibiotics

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.