- AminosalicylatesCorticosteroids for IBDCytokine-Targeted Therapies for IBDJanus Kinase Inhibitors for IBDDrugs Targeting Leukocyte Trafficking for IBDPPAR-γ Ligands for IBDAgents Targeting the TGF-β/Smad System in IBDMatrix Metalloproteinase Inhibitors for IBDImmunotherapies for IBDDrugs Targeting Toll-like Receptors in IBDS1P Receptor Modulators for IBD
- Antibiotic Therapies for IBDProbiotic Therapies for IBDFecal Microbiota Transplantation for IBDCell-based Therapies for IBD
- Drug Target Discovery for IBDLead Discovery for IBDLead Optimization for IBD
- In Vitro ADMEIn Vivo ADME TestingPharmacokinetic EvaluationBioanalysisMetabolite Profiling and IdentificationPreclinical Toxicology Studies for IBD DrugsIn Vitro Efficacy Testing for IBD Drugs
- Disease Activity Index AssessmentColon Length and Weight AssessmentColonoscopyHistology and Immunohistochemistry EvaluationInflammatory Marker AssessmentOxidative Stress Marker AssessmentIntestinal Permeability MeasurementImaging Services
- IBD Immunopathogenesis AnalysisGut Microbiota AnalysisGenetic Studies of IBDIntestinal Barrier Dysfunction in IBD
- Serum Biomarker Discovery for IBDSerological Biomarker Discovery for IBDInquiry
Bioanalytical Services in IBD Drug Development
Bioanalysis is commonly used to characterize quantitative measurements of drugs or their metabolites in biological fluids and can provide valuable insights into the pharmacokinetic profiles of drugs, elucidating their absorption, distribution, metabolism and excretion (ADME) characteristics. Bioanalysis is critical in drug discovery and development. In the early stages of drug discovery, scientists rely on these analyses to screen potential drug candidates, evaluate their pharmacological properties, and prioritize promising leads for further study.
Fig. 1. Possible scenario of bioanalysis in discovering drugs. (Pandey et al., 2010)
Our Bioanalytical Services
At Ace Therapeutics, we provide global bioanalytical outsourcing support for IBD drugs. From method development and characterization to sample collection protocol design, optimized project workflows, and state-of-the-art technology platforms for high-throughput study quality, we provide bioanalytical services suitable for preclinical IBD drug discovery and development.
Ace Therapeutics has leading scientific experts in liquid chromatography-mass spectrometry (LC-MS), high resolution LC-MS, ligand binding assays (LBA), and immunogenicity assays for rapid, accurate, and sensitive quantitative analyses from a variety of biological matrices. Our mission is to consistently provide reliable data to ensure the success of your preclinical IBD drug development program.
Ace Therapeutics' full range of bioanalytical services support the development of small and large molecule drugs for IBD.
- Method Development
- Method Validation
- Lead Optimization Studies
- Pharmacokinetic (PK)/Toxicokinetic (TK) Analysis
- Bioavailability Studies
- Bioequivalence Studies
- Dosage Formulation Analysis
- Immunochemistry Services
- Quantitative Immunoassays
- Immunogenicity Assays
- Biomarkers Assays
- Cell-Based Neutralization Assays
- Ligand-Binding Assays
Why Choose Us
- Dedicated laboratory staff to support your small and large molecule programs
- Custom assay development to support preclinical IBD drug development programs
- Multiple matrices and species
- Wide range of analytical techniques such as chromatography, mass spectrometry, immunochemistry, cell-based assays, flow cytometry, molecular biology
- End-to-end from discovery to non-clinical development
- One company for all your needs
- Provide flexible, responsive support for your IBD drug development programs
Ace Therapeutics' bioanalytical services can help you optimize your IBD drug development program and ensure that you have the technical insight you need to successfully complete your bioanalytical studies. Our experts have the expertise and flexibility to help you develop and validate complex assays to quantify drugs, metabolites, and biomarkers in biological samples. If you are interested in our services, please do not hesitate to contact us.
Reference
- Pandey, S., et al. (2010). Bioanalysis in drug discovery and development. Pharmaceutical methods, 1(1), 14-24.
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