Anti-IL-23R antibody - BSA and Azide free (Detector)

Overview

Product Type	Cell Type Markers
Host Species	Rabbit
Species Reactivity	Reacts with: Human
Application	Sandwich ELISA

Properties

Carrier Free	Yes
Purity	Protein A purified
Clonality	Monoclonal
Conjugate	Unconjugated
Isotype	IgG

Target

Function	Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Tissue Specificity	Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
Sequence Similarities	Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 2 fibronectin type-III domains.
Cellular Localization	Cell membrane.

Storage & Handling

Storage

Store at +4°C. Please refer to protocols.