Cat. No.: IBDAK-621542
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| Product Type | TLR Signaling |
| Host Species | Rabbit |
| Species Reactivity | Reacts with: Mouse |
| Application | Sandwich ELISA |
Properties
| Carrier Free | Yes |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Isotype | IgG |
Target
| Function | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
| Sequence Similarities | Belongs to the NF-kappa-B inhibitor family. Contains 5 ANK repeats. |
| Cellular Localization | Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. |
Storage & Handling
| Storage | Store at +4°C. Please refer to protocols. |