Anti-CD130 (gp130) antibody - BSA and Azide free (Detector)

Overview

Product Type	Cell Type Markers
Host Species	Rabbit
Species Reactivity	Reacts with: Human
Application	Sandwich ELISA

Properties

Carrier Free	Yes
Clonality	Monoclonal
Conjugate	Unconjugated
Isotype	IgG

Target

Function	Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
Tissue Specificity	Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.
Sequence Similarities	Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 5 fibronectin type-III domains. Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Cellular Localization	Secreted and Cell membrane.
Domain	The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The box 1 motif is required for JAK interaction and/or activation.

Storage & Handling

Storage

Store at +4°C. Please refer to protocols.