Anti-CCL4/MIP-1 beta antibody - BSA and Azide free (Capture)

Overview

Product Type	Chemokines
Host Species	Rabbit
Species Reactivity	Reacts with: Human, Monkey
Application	Sandwich ELISA

Properties

Carrier Free	Yes
Purity	Protein A purified
Clonality	Monoclonal
Conjugate	Unconjugated
Isotype	IgG

Target

Function	Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Sequence Similarities	Belongs to the intercrine beta (chemokine CC) family.
Cellular Localization	Secreted.

Storage & Handling

Storage

Store at +4°C. Please refer to protocols.