Cat. No.: IBDAK-621825
Size:
Online InquiryOverview
| Product Type | Chemokines |
| Host Species | Rabbit |
| Species Reactivity | Reacts with: Human |
| Application | Sandwich ELISA |
Properties
| Carrier Free | Yes |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Isotype | IgG |
Target
| Function | Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses. |
| Tissue Specificity | Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid. |
| Sequence Similarities | Belongs to the intercrine beta (chemokine CC) family. |
| Cellular Localization | Secreted. |
Storage & Handling
| Storage | Store at +4°C. Please refer to protocols. |