Anti-AGRP antibody - BSA and Azide free (Capture)

Overview

Product Type	Redox Metabolism
Host Species	Rabbit
Species Reactivity	Reacts with: Human
Application	Sandwich ELISA

Properties

Carrier Free	Yes
Clonality	Monoclonal
Conjugate	Unconjugated
Isotype	IgG

Target

Function	Plays a role in weight homeostasis. Plays a role in the central control of feeding. Reduces food intake. Inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Acts primarily on MC3R and MC4R. Has very low activity with MC5R.
Tissue Specificity	Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
Sequence Similarities	Contains 1 agouti domain.
Cellular Localization	Secreted. Golgi apparatus lumen.
Domain	The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Storage & Handling

Storage

Store at -20°C. Please refer to protocols.