Analysis of the Genetics of IBD

Inflammatory bowel disease (IBD) has been a key area of genetic research in complex diseases. Various studies have identified more than 240 genetic variants related to IBD. These genetic variants are involved in innate and adaptive immunity, autophagy, defective bacterial handing, interleukin-23 (IL-23) and IL-10 signaling, and so on. Genetic studies of IBD have helped to provide key information on the underlying mechanisms of the disease, provide gene pathways for effective drug design targets, and develop therapeutic and preventive strategies.

Fig. 1. Analysis of the genetics and epigenetics of IBD. Fig. 1. Genetics and epigenetics of IBD. (Annese et al., 2020)

Our Genetic Research Services

Ace Therapeutics provides comprehensive genetic research services to help clients analyze the genetic background of IBD. Using DNA analysis and sequencing technology platforms, our experienced team of experts can analyze gene-gene interactions, gene-pathway interactions, and gene-environment interactions. We aim to improve the understanding of IBD pathological mechanisms required for the development of new therapeutics.

Our genetic research services can provide high-quality, reproducible data for your IBD research program. We will help you determine the appropriate techniques, experimental designs, and objectives to realize the full potential of your project.

Identification of IBD-associated Gene Loci

We provide genome-wide association studies (GWAS) and next-generation sequencing (NGS) to identify genes (e.g., NOD2, ATG16L1, CARD9, CLEC7A, IL-10) associated with the risk of developing IBD. We perform comprehensive genetic, bioinformatic, and laboratory evaluations of these association signals to help clients better identify susceptibility genes and susceptibility alleles, especially when the association signal spans multiple candidate genes.

Study the Epigenetic Mechanisms of IBD

We help our clients explore the role of epigenetic modifications (DNA methylation, post-translational modification of histones, expression of non-coding RNAs) in IBD and gain insight into how these changes affect gene expression and disease manifestation. By identifying epigenetic features in IBD, we develop new biomarkers for IBD.

Study the Role of Susceptibility Gene in IBD

We help our clients to investigate the role of these genes in the pathogenesis of IBD, including the impact on the microbiome and the immune-immune system. We offer a wealth of mouse models with induced or spontaneous mutations in multiple genes to analyze the complex interrelationships of the lifelong host response to gut flora and to identify the multiple pathways that may lead to IBD.

The complexity of genetic factors contributing to murine IBD is illustrated by using induced or spontaneous mutant mice to map IBD modifier genes.

The C3H/HeJ and C57BL/6 strains are identified as highly susceptible and resistant genotypes, respectively, and used for QTL analysis of IL-10-deficient mice.
Genome-wide linkage analysis is performed on crosses of spontaneous ileal SAMP1/YitFc mice with drug-resistant C57BL/6 strains.

Our Advantages

Our experts combine multiple advanced technologies (GWAS, NGS, epigenetic approaches, bioinformatics) to study the function of IBD-related genes in IBD animals.
We help our clients' IBD drug discovery efforts by identifying gene pathways for effective targeting.
We help our clients develop biomarkers to measure disease activity, pathophysiological mechanisms, or therapeutic response.

As a leading service provider in the field of IBD, Ace Therapeutics assists our clients in the comprehensive analysis of loci/genes associated with IBD. Through our genetic research services, we provide data to support the study of IBD pathomechanisms and the development of therapies. If you are interested in our services, please do not hesitate to contact us.

Reference

Annese, V. (2020). Genetics and epigenetics of IBD. Pharmacological research, 159, 104892.

! For research use only, not intended for any clinical use.