Cat. No.: IBDP-531852
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Online InquiryTarget Information
| Sequence | Ac-FEWTPGWYQ-{Aze}-YALPL-NH2 |
| Function | AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC50=8 nM) but not the human type II receptor (IC50=6.7 µM) or the murine type I receptor (IC50>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC50=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC50=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo. |
Product Details
| Product Type | Peptide |
| Cas | 185413-30-3 |
| Molecular Weight | 1895.12 kDa |
| Purity | 0.9975 |
Storage & Handling
| Shipping | Shipped at Room Temperature. |
| Storage | Store at -20 °C or -80 °C. |
| Handling | Avoid freeze / thaw cycle. |