7α,25-Dihydroxycholesterol

Cat. No.: IBDI-430995

7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells.

Product Details

Target	EBI2/GPR183 | Endogenous Metabolite
Molecular Weight	418.65
Appearance	Solid
Synonyms	7α,25-OHC
SMILES	C[[email protected]@]12[[email protected]](CC[[email protected]]2([H])[[email protected]](C)CCCC(C)(O)C)([H])[[email protected]@]3([H])[[email protected]]([[email protected]@]4(C(C[[email protected]@H](O)CC4)=C[[email protected]]3O)C)([H])CC1
Structure Classification	Steroids
Purity	98.05%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.