20(S)-Hydroxycholesterol

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Cat. No.: IBDI-430975

20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells.

Size (Solution): 10 mM * 1 mL in DMSO

Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution

Size (Solid):

Product Details

Target	Smo \| Endogenous Metabolite
Molecular Weight	402.65
Appearance	Solid
Synonyms	20α-Hydroxycholesterol
SMILES	C[[email protected]@]1([[email protected]@]2([H])[[email protected]@](C)(O)CCCC(C)C)[[email protected]](CC2)([H])[[email protected]@](CC=C3[[email protected]@]4(CC[[email protected]](O)C3)C)([H])[[email protected]]4([H])CC1
Structure Classification	Steroids
Purity	98.70%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.