2-Methoxyestradiol

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Cat. No.: IBDI-430673

2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa.

Size (Solution): 10 mM * 1 mL in DMSO

Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution

Size (Solid):

Product Details

Target	Microtubule/Tubulin \| Reactive Oxygen Species \| Apoptosis \| Autophagy \| Endogenous Metabolite
Molecular Weight	302.41
Appearance	Solid
Synonyms	2-ME2, NSC-659853
SMILES	OC1=CC2=C([[email protected]]3(CC[[email protected]@]4([[email protected]](CC[[email protected]]4([[email protected]@]3(CC2)[H])[H])O)C)[H])C=C1OC
Structure Classification	Phenols
Purity	99.60%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.