Proteomic Analysis of Glaucoma

Glaucoma is a neurodegenerative ocular disease whose physiopathological molecular mechanisms are still far from being understood. Proteomics studies can help researchers uncover glaucoma-related changes in different tissues and biological fluids of the eye.

Proteomics results will advance the understanding of glaucoma. For different ocular regions and biological fluids, Ace Therapeutics can provide a high-throughput approach to molecular information about glaucoma through the use of state-of-the-art proteomics technologies, making an important contribution to the understanding of molecular and biochemical pathways associated with glaucoma.

Services for Proteomic Analysis of Glaucoma

AH

Aqueous humor (AH) is a clear fluid located in the front of the eye and is produced by the part of the eye called the ciliary body, which is located above the lens of the eye. AH is a key site for studying the pathogenesis of glaucoma, and the balance between its secretion and drainage is important for maintaining IOP. Therefore, Proteomic characterization of AH may contribute to the understanding of the pathophysiology of glaucoma and identifying candidate proteins involved in glaucoma.

VH

Vitreous humor (VH) is a highly hydrated, clear gel-like substance located in the posterior segment of the eye between the lens and the retina. Some of the physiological and pathological conditions of the retina due to glaucoma can be reflected in the protein composition of the VH. We provide different proteomics services for the analysis of VH to assist researchers in discussing and expanding their findings on glaucoma, using proteomics studies to report important insights into the possible pathogenesis of glaucoma.

Retinal

Neurodegenerative changes in the internal retina are a pathological feature of glaucoma. Advancing proteomics technologies allow large-scale analysis of the structure, function and interactions of proteins in retinal tissue. Exploring the retinal proteome can provide insight into proteomic alterations and the underlying pathological mechanisms of glaucoma. We can assist researchers in studying the changes in retinal protein expression in glaucoma.

TM

Trabecular meshwork (TM) is a tissue in the eye responsible for regulating aqueous humor (AH) outflow and controlling intraocular pressure (IOP). Since IOP is a major risk factor for glaucoma, TM tissue plays an important role in the pathogenesis of glaucoma. Therefore, understanding the unique proteomic alterations of TM tissue is an important point in the study and prevention of glaucoma. We aim to enhance the understanding of glaucoma at the molecular level by analyzing the TM proteome of glaucoma models.

Glaucoma Proteomics Analysis

• Sample preparation of different ocular tissues and biological fluids associated with glaucoma.
• Best proteomics strategy and comprehensive proteomics services.
• Advanced technologies such as mass spectrometry and bioinformatics.
• Accurate and reproducible results.
• Competitive price.

Applications

• To provide more critical information for understanding the pathophysiology of glaucoma.
• To understand the molecular interactions of different ocular components and biological fluids in glaucoma.
• To find glaucoma-related biomarkers.
• To explore pathogenic pathways and new therapeutic targets in glaucoma.

At Ace Therapeutics, we specialize in glaucoma research using proteomic analysis to address both basic research and practical applications related to glaucoma. As an integrated contract service provider, we can perform all sample preparation, complex analytical experiments, and data analysis using our state-of-the-art equipment and facilities. Our services are individually tailored to your specific needs.

Reference

1. Sebastian, et al. The potential impact of recent insights into proteomic changes associated with glaucoma. Expert Review of Proteomics, 2017, 14(4):311-334.