As a preclinical ophthalmic CRO, Ace Therapeutics provides ocular toxicology studies of glaucoma drugs, primarily including tolerability and safety assessment services. With our experienced ocular pathology team, we provide critical tolerability and safety data for various small molecules, biologics, cellular therapies, gene therapies, and other new therapies or drugs by performing specialized toxicology evaluations in various animal models.
Ocular Toxicity Assessment in Animal Models
Glaucoma drug therapy is being optimized, and some novel therapies or drugs should undergo rigorous safety and tolerability reviews. Before proceeding to clinical trials, pharmaceutical and biotechnology companies must present evidence of the drug's biological activity and provide data showing that the drug is reasonably safe.
One or more adverse changes that affect the structure or function of the eye after the drug is applied directly to or within the eye is called ocular toxicity. In glaucoma treatment, the primary mode of drug delivery is currently acting on individual tissues of the eye. Therefore, specially bred animal models can provide research scientists with detailed information about the efficacy and safety of drugs developed to address glaucoma in humans. Biotechnology and pharmaceutical companies across the country can collaborate with us to evaluate glaucoma therapies under development.
Services for Ocular Tolerability and Safety Study for Glaucoma Drugs
Whether you are developing a new drug molecule or an optimized product, or a new drug delivery system, we provide you with toxicological assessments for ocular therapies, providing critical tolerability and safety data. Our ocular tolerability studies are conducted in a variety of animal models, including rodents, rabbits, dogs, etc., with various routes of administration. We will customize a safety evaluation program to meet your needs, including but not limited to maximum tolerated dose (MTD) and ocular histopathology evaluation.
- Ocular histopathological analysis. We offer experienced laboratory staff and specialized techniques dedicated to the detailed analysis of every structure of the eye. We are able to use a variety of techniques and perform specialized evaluations, including biopsy, tissue sectioning, microscopic examination, immunohistochemical staining, and more.
- Acute/chronic toxicity measurements. For a variety of dosage forms such as eye drops, gels, ointments, granules, inserts, etc., which can be administered via various routes of administration such as intravitreal, subconjunctival, retrobulbar, periocular, intraocular, and subretinal injections in animal models, stimulation tests are performed over short and long periods of time to record individual characteristics, ocular tissue characteristics, and other data.
- Assessment services. We can provide many measurement services such as electroretinography, spectral domain optical coherence tomography, fundoscopy, angiography, tissue body fluid collection, microscopy, and ultimately the evaluation of IOP, microscopic evaluation, histopathological examination, ocular and systemic tissue distribution, tear measurement, corneal examination, and many other data.
Our Advantages
- Our glaucoma model is designed to provide accurate results in a fast, cost-effective manner.
- All eye examinations are performed by veterinary ophthalmologists according to standard guidelines, thus providing great confidence in the results obtained.
- Our service is a regulatory safety program that meets Good Laboratory Practice (GLP) standards.
As a leading CRO dedicated to glaucoma research, Ace Therapeutics collaborates with our clients on all preclinical studies involving this field. Do you need a relevant in vivo research program, contact us and let us help.