Metabolomics has been used to study a variety of ocular diseases, including glaucoma. Many metabolomics studies have been applied to glaucoma diagnosis and pathogenesis in recent years. Metabolomics of ocular and systemic samples may contribute to a better understanding and early diagnosis of glaucoma.
The general characteristics of metabolite changes in glaucoma are glutamate, sphingosine, phosphorylcholine, and phosphatidylcholine. Some studies have performed metabolome-wide analyses of glaucoma patients and found significant differences in specific metabolic processes involving palmitoylcarnitine, sphingolipids, vitamin D-related compounds, and steroid precursors. Alternatively, metabolomic analysis of phenotypic samples within glaucoma, such as atrial fluid, may help to identify glaucoma biomarkers more accurately.
As a contract service provider focused on glaucoma research, Ace Therapeutics can offer glaucoma-related metabolomics research services to explore further knowledge about the pathophysiology behind glaucoma and biomarkers that may be used as diagnostic, classification and treatment progression, and may also identify new lines of drug development.
Services for Metabolomic Analysis of Glaucoma
Aqueous humor (AH) plays an important role in the pathogenesis of glaucoma. AH contains a wide range of metabolites and more than 200 have been identified, including carbohydrates, amino acids, urea, ascorbic acid, glutathione organosolutes, adenosine, xanthine, polyamines, fatty acids, acylcarnitine, and phospholipids, involved in more than 40 metabolic pathways. The metabolomic analysis of glaucomatous AH may provide potential biomarkers and expand our understanding of pathophysiology.
Blood is also a valuable biospecimen for glaucoma metabolomics because it is easy to collect and has a high reproducibility. And metabolites from AH and plasma may have large synchronous trends that can provide information about normal and pathological conditions. We can apply cutting-edge technologies for detecting glaucoma-related metabolites to provide researchers with state-of-the-art metabolomic analysis services in glaucoma research.
Features and Advantages
- High resolution with high quality accuracy instruments and rigorously tested assays are available for reliable metabolite identification and excellent performance assurance.
- Perform wide dynamic range, highly multiplexed metabolite quantification in a variety of complex biofluids and ocular tissue types.
- Rigorous quality control with reliable guarantees for sensitivity, linearity, reproducibility, reliability and stability.
- A dedicated glaucoma team provides personalized metabolomics services for different glaucoma programs.
Request for Services
As a service platform, we can provide metabolomics analysis services as flexibly as possible, ready to design custom solutions to meet our clients' needs. We look forward to working closely with you. A general flow of information about our services is shown below.
Fig. 1 Workflow for glaucoma metabolomics analysis.
Ace Therapeutics offers a powerful metabolomics approach that can identify the metabolic signature of glaucoma pathological conditions, thus providing a means to discover biomarkers and new drug therapies. You can request our service to measure small molecule metabolites in plasma, aqueous humor in glaucoma, to achieve quantitative and comparable results in different studies for all clients, and to facilitate the interpretation of data for each researcher.
You can request a quote by filling out the form below, and after signing the agreement you can send us samples for analysis. Ultimately you will receive the metabolomic characterization results, and if you have any questions, please contact us.
References
- Tang Y Z, et al. Advances in metabolomics research of glaucoma. International Review of Ophthalmology, 2019, 43(5):294-299.
- Barbosa-Breda J, et al. Clinical Metabolomics and Glaucoma. Ophthalmic Research Journal for Research in Experimental & Clinical Ophthalmology, 2018, 59:1-6.