The use of in vitro systems to study glaucoma is an excellent strategy. Although in vitro models cannot mimic the complexity of glaucoma, they do provide new insights into the molecular mechanisms of glaucoma progression and therapy development in a faster and less expensive manner. Also, we need accurate in vitro ocular models to initially assess the safety of glaucoma drugs.
Ace Therapeutics provides in vitro studies of cell-based models for glaucoma, exploring glaucoma-related molecular mechanisms in trabecular meshwork (TM), retinal ganglion cells (RGCs) and other cell types and in vitro characterization of anti-glaucoma drugs, bringing validated preclinical data.
In Vitro Cell-Based Models
The use of in vitro models to study glaucoma can help us elucidate the mechanisms of glaucoma pathology. The development of appropriate in vitro models is essential for the development of glaucoma therapies. In vitro models can be used to evaluate many experimental parameters involved in basic science, drug development, toxicology studies, and other fields. Therefore, many scientists have derived various alternative in vitro models from animal and human primary cells. These models include a variety of cell cultures and even tissue cultures. And compared to in vivo models, in vitro cell-based models have the advantages of being simple, rapid to construct, relatively inexpensive and reproducible.
Services for In Vitro Study for Glaucoma
We focus on providing the design and culture of in vitro models for glaucoma research that simulate high intraocular pressure (IOP) through pressure elevation in in vitro systems.
IOP is the only modifiable risk factor for glaucoma, and IOP is regulated primarily by aqueous humor (AH) flow from the TM. Therefore, the use of TM cell models is necessary to understand in vitro outflow physiology and glaucoma pathology. We offer TM in vitro model construction services for glaucoma research, allowing our clients to conduct human cell-based studies to more effectively understand the molecular mechanisms that contribute to glaucoma disease.
Glaucoma is primarily characterized by progressive degeneration of the optic nerve. Optic nerve damage is caused by the death of RGCs, and therefore the death of RGCs is a critical stage in the pathogenesis of glaucoma. We offer RGC in vitro model construction services for glaucoma research, allowing our clients to conduct human cell-based studies to more effectively understand the molecular mechanisms that contribute to glaucoma disease.
Applications
Our in vitro ocular cell modeling services can be used in a wide range of research areas including, but not limited to.
- Cell physiology
- Tissue engineering
- Toxicological screening
- Permeability studies
- Drug uptake
- Translational studies
Our Significant Advantages
Our in vitro study services provide our clients with useful data to complement the results of in vivo studies.
- Controlled environment
- Controlled cell composition
- Less time consuming
- Reduced variability
- Significant cost advantages
Contact us to explore how we can provide comprehensive preclinical in vitro research services for your glaucoma program.
Reference
- Sara Shafaie, et al. In Vitro Cell Models for Ophthalmic Drug Development Applications. Bio Research Open Access, 2016,94-108.