The use of animal models in glaucoma research is a powerful translational tool for the development of new therapies for human glaucoma. We should consider the strengths and limitations of various models in their design and construction, and successfully apply the results of animal experiments.
In the face of the challenges of glaucoma treatment, it is necessary to develop new preclinical animal models to mimic human glaucoma to try out new treatment strategies. Ace Therapeutics designs and develops the ideal animal research model for glaucoma researchers to use to investigate and validate the scientific question or treatment program you are investigating.
About Glaucoma Model Research
The main forms of human glaucoma are open-angle, closed-angle, glaucoma caused by other diseases, and developmental glaucoma. The main features of the disease are damage to the optic nerve head (ONH) and apoptosis of retinal ganglion cells (RGCs). Therefore, the main features of an appropriate animal model that replicates the key features of human glaucoma are the same.
The original animal models of glaucoma use methods to increase IOP by blocking atrial aqueous outflow. This approach includes various physical, chemical, and other pathways. The use of these methods produces histological changes that mimic the pathology of human glaucoma. In order to simulate the phenotypes of different types of glaucoma with greater precision, there is a desire to develop mouse models of glaucoma that harness the power of mouse genetics and genetic techniques. Later, spontaneous glaucoma in animals has also been effectively exploited, including species such as dogs, chickens and rabbits.
Services for Glaucoma Animal Model Construction
Currently, researchers are characterizing glaucoma and replication-related damage with high precision in a range of species. The vast majority of studies have been conducted in primates and rodents, and various models have been developed for different species. We are attempting to relate the findings of various animal models to specific types of glaucoma by developing various models for different species, including monkeys, rats, mice, rabbits, dogs, pigs, etc.
Elevated IOP is a major risk factor for the development and progression of glaucoma. Animal models of glaucoma that mimic IOP elevation can greatly improve our understanding of the molecular mechanisms of glaucoma and serve as a useful tool for drug screening. We offer a wide range of services for the development of IOP-dependent animal models of glaucoma through experimentally induced methods including various physical, chemical, and biological pathways.
For each type of glaucoma, a single animal model of high IOP may not accurately simulate the different glaucoma forms. Compared to experimentally induced glaucoma models, genetic glaucoma animal models are able to more precisely control molecular pathways to simulate different types of glaucoma. We provide advanced cell biology and powerful genetic tools for use in laboratory mice and is dedicated to constructing many new mouse models of glaucoma.
Our Highlights
- Easy to induce
- Repeatable
- Low-cost
- Glaucoma pathology as similar as possible to that of humans
Although there is no perfect experimental model, we are committed to developing each model that can be successfully used in glaucoma research and the development of new therapies. We hope to work with you to open up new avenues of research to study the pathophysiology of glaucoma and drug development using animal models.
Reference
- Quigley, H A. Use of Animal Models and Techniques in Glaucoma Research: Introduction. In: Glaucoma. Methods in Molecular Biology, 2018,1695.