Drug formulations for glaucoma currently suffer from generally low bioavailability and unsustainable drug release. Therefore, the development of new glaucoma drug delivery systems plays an important role in order to overcome these drawbacks.
Ace Therapeutics provides research services to develop convenient, safe and effective sustained-release drug delivery systems for the efficient treatment of glaucoma. Our services include the development and validation of several new drug delivery systems such as in-situ gels, liposomes, hydrogels, dendrimers, nanoparticles, etc., to explore the impact of these novel drug delivery systems for the treatment of glaucoma.
Services for Drug Delivery System Development for Glaucoma
In-situ gel systems are systems in which a liquid formulation is converted into a thin layer of gel after being mounted in the eye. The essence of such systems is to enhance therapeutic efficacy through drug release and contact time caused by sol-gel conversion and mucosal adhesion behavior. We offer in-situ gel system development services for glaucoma drug delivery, including the formulation of various responsive polymers, control of gel formation, drug release rates and a range of other studies.
Treatment of glaucoma with ocular drugs requires overcoming the corneal barrier and increasing drug penetration and absorption. Liposomal formulation can be one of the drug carriers of choice. Liposomes include an aqueous inner core and an outer lipid layer, which gives liposomes their unique properties. They can deliver hydrophilic and hydrophobic drugs to the eye. We are dedicated to developing biocompatible, biodegradable and non-hazardous liposome formulations to deliver drugs to the eye for the treatment of glaucoma.
Hydrogels are an important class of soft materials that can encapsulate and deliver a variety of glaucoma drugs. Based on their porous and cross-linked structure, these cross-linked polymers facilitate the carriage of drugs. The wide range of customizability and high hydrophilicity make hydrogels ideal compounds for glaucoma drug delivery applications. We offer glaucoma drug delivery system development services and is committed to designing a suitable hydrogel system for our customers.
Dendrimers are made of polymeric materials with extensive and flexible branching, multiple surface groups, unique structures and high-water solubility. Due to their structure, dendrimers can interact with drug molecules to form physical complexes or chemical adducts, thereby increasing bioavailability, cellular uptake and therapeutic efficacy. We are committed to developing innovative, effective and less burdensome dendrimer delivery systems.
Nanoparticles offer significant advantages in protecting the drug from degradation and maintaining its structural integrity. Nanoparticles are also capable of increasing the penetration of drugs through the ocular barrier. Therefore, nanoparticle-based drug delivery systems have potential applications in the ocular treatment of glaucoma. We offer development services for nanoparticle delivery systems composed of various types of polymers and is committed to improving barrier permeability and slow release of drugs.
Applications
- Deliver drugs with high specificity to their target cells
- Improve the efficacy of conventional drugs at least better than current levels
- Low risk and acceptable repeat dosing
Let Us Be Your Partner
Glaucoma is a disease that irreversibly damages the eye nerves. A continuous drug delivery system offers hope for individuals with glaucoma. It is important to formulate different advanced drug delivery systems to improve the efficacy of the drug.
We conduct careful development of glaucoma drug delivery systems, working to improve drug efficacy and sustained release. Let us be your partner in bringing new possibilities to glaucoma treatment.
Reference
- Rahić O, et al. Novel Drug Delivery Systems Fighting Glaucoma: Formulation Obstacles and Solutions. Pharmaceutics, 2021, 13, 28.