Glaucoma is a group of ocular diseases that may lead to progressive retinal ganglion cell death and irreversible vision loss. Although our understanding of glaucoma is much more advanced than before, our understanding of its molecular mechanisms still requires a great deal of basic research to further understand it.
Ace Therapeutics' research team consists of leading scientists studying the mechanisms of glaucoma and glaucoma treatment, and we collaborate in basic research, therapy development, and preclinical studies in glaucoma. The main areas of basic glaucoma research include genetics, genomics, proteomics, metabolomics, and biomechanics of glaucoma. We are committed to conducting extensive research to better manage glaucoma and to provide possible directions for glaucoma treatment.
Services for Basic Research in Glaucoma
- Genome-Wide Association Studies with POAG
Primary open-angle glaucoma (POAG) is the most common form of glaucoma, and known risk factors for POAG include advanced age, high intraocular pressure (IOP), reduced central corneal thickness (CCT), and high myopia. GWAS have successfully identified dozens of single SNPs associated with POAG. We provide our clients POAG's GWAS services to identify new SNPs for different endophenotypes, including IOP, CA, DA, VCDR, CCT and other association studies of interest, and to fully explore the mechanisms of glaucoma. - Proteomic Analysis of Glaucoma
Glaucoma is a neurodegenerative ocular disease whose physiopathological molecular mechanisms are still far from being understood. Proteomics studies can help researchers uncover glaucoma-related changes in different tissues and biological fluids of the eye. We can provide a high-throughput approach to molecular information about glaucoma through the use of state-of-the-art proteomics technologies, making an important contribution to the understanding of molecular and biochemical pathways associated with glaucoma. - Metabolomic Analysis of Glaucoma
Metabolomics has been used to study a variety of ocular diseases, including glaucoma. Metabolomics of ocular and systemic samples may contribute to a better understanding and early diagnosis of glaucoma. We can offer glaucoma-related metabolomics research services to explore further knowledge about the pathophysiology behind glaucoma and biomarkers that may be used as diagnostic, classification and treatment progression, and may also identify new lines of drug development. - Biomechanical Analysis of Glaucoma
Biomechanics is an essential aspect of glaucomatous disease. In all forms of glaucoma, different ocular tissues have some biomechanical role, including the trabecular meshwork (TM), optic nerve papillae (ONH), cornea, and among others. We provide research services to explore the central role of ocular tissue biomechanics in glaucoma, using biomechanical modeling, micromechanical testing and in vivo imaging to assess the mechanical properties of relevant tissues and discuss their future applications in understanding and treating glaucoma.
Key Research Questions
Table 1. Our specific solutions for key research questions in glaucoma.
| Key Research Questions | Our Solutions |
|---|---|
| SNPs of different endophenotypes associated with POAG | To develop solutions for association studies including IOP, CA, DA, VCDR, CCT and other risk factors of interest, and to fully explore the mechanisms of glaucoma. |
| Protein molecules and biochemical pathways associated with glaucoma | Using state-of-the-art proteomics technology to provide a high-throughput approach to molecular information in glaucoma. |
| Glaucoma biomarkers | To provide glaucoma-related proteomics and metabolomics studies to further explore the pathophysiology behind glaucoma, as well as to discover biomarkers that can be used for diagnosis, classification and therapeutic progression. |
Why Choose Our Research Services
- To better understand the molecular mechanisms and risk factor effects of glaucoma.
- To improve scientific understanding of glaucoma and find new treatments.
- To provide potential directions for future therapeutic research in glaucoma.
We are committed to helping scientists make progress in the field of basic glaucoma research, providing potential research directions for drug development and clinical treatment. If you need a lot of basic research and data to better explore glaucoma. You can contact us to get the service you want.