Ace Therapeutics has extensive experience in the field of gastrointestinal disease research. We can provide customized services for preclinical irritable bowel syndrome (IBS) research to support clients' research and development needs, including disease model development and new drug development.
Introduction to IBS
IBS is a common functional bowel disorder characterized by abdominal pain or discomfort. Pathologically, IBS involves dysregulation of the gut-brain axis, visceral hypersensitivity, and changes in the gut microbiota. IBS usually has no detectable organic etiology, making its diagnosis and treatment more challenging.
In recent years, drug development research strategies for IBS include symptom control, novel mechanism-based drugs, and personalized therapy. Common drug types for IBS drug development are shown below.
- 5-Hydroxytryptamine Receptor Modulators
- Bile Acid Transporter Modulators
- Intestinal Mucosal Protective Agents
- Intestinal Microecology-Based Treatment
Fig. 1 Pathology of irritable bowel syndrome in the intestinal. (Huang KY, et al., 2023)
What Can We Do?
We offer exclusive services for our clients' IBS research, including IBS animal modelling, new drug discovery, as well as diagnostic methodology and technology development services.
IBS Model Development Services
Based on our rich research experience in the field of animal model construction, we can help our clients develop appropriate experimental animal models according to their IBS research goals.
- Chemical-induced Animal Models
- Microbiota-related Animal Models
- Genetic Animal Models
Basic Research Service on IBS
IBS is a gastrointestinal disorder with a complex etiology, and its exact pathogenesis remains unclear. We provide a variety of basic research services, including the identification of novel IBS biomarkers, and multi-omics analyses or gut microbiota studies to analyze the underlying pathological mechanisms.
IBS Drug Development Services
Based on the symptoms and causes of IBS, we can provide our clients with different types of drug development services for IBS therapy.
- We can help develop novel gastrointestinal promotility drugs to relieve abdominal pain and bloating by modulating intestinal motility to relieve IBS symptoms.
- We can help develop intestinal immunomodulatory inhibitors to alleviate IBS symptoms by modulating the immune response.
- We can also identify new specific targets for IBS therapy and develop therapeutic drugs based on the new targets through high-throughput screening.
Ace Therapeutics has comprehensive technology platforms for gastrointestinal disease research. Based on clients' research needs, we are confident to provide professional customized IBS research services. If you would like to learn more about our services, please do not hesitate to contact us.
Reference
- Huang, K.Y.; Wang, F.Y.; Lv, M.; et al. Irritable bowel syndrome: Epidemiology, overlap diseases, pathophysiology and treatment. World J Gastroenterol. 2023, 29(26):4120-4135.
Related Services
Our products and services are for research use only and can not be used for diagnostic or other purposes.
