Ace Therapeutics has extensive experience in various types of gastrointestinal (GI) disease research. We are dedicated to solving the challenges our clients face in the development of novel drug candidates for GI diseases. We offer customized preclinical services to support gastroesophageal reflux disease (GERD) research and development needs of clients.
Introduction to GERD
GERD refers to a collection of discomforting symptoms caused by the backflow of stomach contents, rich in stomach acid, into the esophagus. Unlike the stomach mucosa, the esophageal mucosa is less resistant to acid, leading to inflammation in the esophagus.
In recent years, there have been a lot of new advances in drug research of GERD. Drug development strategies for the treatment of GERD involve the inhibition of gastric acid secretion and the promotion of gastrointestinal motility, which include the following common drug types.
- Proton Pump Inhibitors (PPIs)
- H2 Receptor Antagonists (H2RAs)
- 5-HT4 Receptor Agonists
- Potassium Competitive Acid Blockers (P-CABs)
- GABA Receptor Agonists
- Mucosal Protective Agents
Fig. 1 The complex pathogenesis of GERD. (Chhabra P, 2022)
What Can We Do?
We can provide exclusive services for different areas of GERD research, including but not limited to animal model development, pathogenesis research, drug development, and diagnostic technology development services.
GERD Model Development Services
Experimental models are important tools to carry out GERD research, and we can provide with professional experimental model development services to meet clients' needs in GERD research.
- Cell Culture Models of GERD
- In Vitro Organoid Models of GERD
- Animal Models of GERD
Basic Research Services for GERD
The pathogenesis of GERD has not yet been elucidated. We can provide a variety of basic GERD research, including the discovery of highly specific GERD biomarkers, and the study of the underlying pathogenesis from the perspective of gene and protein expression, metabolites, or intestinal flora regulation.
Drug Development Services for GERD
Pharmacological strategies for GERD focus on controlling and reducing acid reflux symptoms and alleviating esophageal inflammation and complications. We can provide targeted drug development services for GERD through the following strategies.
- We help evaluate the inhibitory effects of drugs on H+/K+ ATPase, H2 receptors, and calcium channels in gastric mucosal cells to test the efficacy of drugs in reducing gastric acid secretion.
- For gastric mucosal protectants and antacids, we can help evaluate their ability to neutralize gastric acid or enhance the barrier function of the gastric mucosa.
- We can also identify new targets and drug candidates using high-throughput screening and molecular biology techniques.
Ace Therapeutics has a team that can provide specialized research services in the field of GERD. We will develop customized service plans according to experimental needs of clients. If you would like to learn more about our services, please do not hesitate to contact us.
Reference
- Chhabra, P.; Ingole, N. Gastroesophageal reflux disease (GERD): highlighting diagnosis, treatment, and lifestyle changes. Cureus. 2022,14(8):e28563
Related Services
Our products and services are for research use only and can not be used for diagnostic or other purposes.
