Ace Therapeutics has been deeply involved in the field of gastrointestinal disease research for many years. We can provide you with professional preclinical research services to make breakthroughs in basic research and novel drug development in the field of gastritis research.
Introduction to Gastritis
Gastritis is an inflammatory response of the gastric mucosa that can be caused by a variety of etiologic factors and is one of the most common gastrointestinal diseases. According to the causes, gastritis can be categorized into Helicobacter pylori-associated gastritis, stress gastritis and autoimmune gastritis.
In recent years, the development strategy about gastritis drugs mainly focuses on inflammation inhibition, gastric mucosa protection, and etiological treatment, among which anti-inflammatory drugs are the hotspot of gastritis drug development research. The main drug therapeutic development strategies of gastritis are as follows.
- Selective COX-2 Inhibitors
- Inflammatory Cytokine Antagonists
- Gastric Mucosal Repair Agents
- Probiotic Therapy
Fig.1 Pathogenesis, diagnosis, clinical presentation of autoimmune atrophic gastritis, and risk of malignancy. (Castellana C, et al., 2024)
What Can We Do?
We can provide exclusive services for gastritis research, including animal modeling services, novel therapeutic drug development services, and various basic research services. Regardless of the type of gastritis research, our scientists will deliver the customized research services to our clients.
Gastritis Model Development Services
Appropriate models are essential for preclinical studies of gastritis. We offer the following gastritis animal modeling services, including rodents (rats and mice) and large mammals such as pigs.
- Chronic Atrophic Gastritis Models
- Acute Gastritis Models
- Autoimmune Gastritis Models
Basic Research Services for Gastritis
Gastritis is one of the most prevalent gastrointestinal diseases, and timely, accurate diagnosis is essential for effective detection and treatment. We offer a range of basic research services, including the identification and characterization of biomarkers for gastritis diagnosis, as well as in-depth studies on its pathogenesis, tailored to meet the specific needs of different research projects.
Drug Development Service for Gastritis
We offer innovative gastritis drug development services, including the development of symptomatic therapies such as reducing gastric acid secretion, neutralizing acid, and protecting the gastric mucosa, as well as etiological therapies like targeting Helicobacter pylori infection.
- We can evaluate the inhibitory effect of the drug on H+/K+ ATPase and H2 receptors on gastric mucosal cells.
- We assess the function of antacids and gastric mucosal protectants in neutralizing gastric acid, enhancing gastric mucosal barrier function, preventing gastric acid erosion and promoting mucosal healing in animal models.
- We can investigate new pathophysiological mechanisms to alleviate gastric mucosal inflammation and discover new therapeutic targets for the treatment of gastritis.
Ace Therapeutics has a team of experts specializing in gastrointestinal diseases, capable of offering customized gastritis research services to our clients' experimental needs. If you would like to know more about our services, please do not hesitate to contact us.
Reference
- Castellana, C.; Eusebi, L.H.; Dajti, E.; et al. Autoimmune Atrophic Gastritis: A Clinical Review. Cancers (Basel). 2024, 16(7):1310.
Related Services
Our products and services are for research use only and can not be used for diagnostic or other purposes.
