Ace Therapeutics is committed to providing customized preclinical research services to address the challenges our clients facing in gastric ulcer research. Our research services include the development of gastric ulcer models, the discovery of biomarkers for gastric ulcer, and the development of novel drugs for the treatment of gastric ulcers.
Introduction to Gastric Ulcer
Gastric ulcer is a common digestive disease clinically characterized by ulceration of the gastric mucosa. Gastric ulcers are mainly caused by Helicobacter pylori infection or by damage to the gastric mucosa due to nonsteroidal anti-inflammatory drug (NSAID) overdose.
Gastric ulcers are mainly caused by the destruction of the gastric mucosa. Therefore, the drug treatment strategy of gastric ulcers involves repairing the mucosal damage or resisting the destructive factors to the gastric mucosa. Currently, common drug development strategies for gastric ulcer include:
- Proton Pump Inhibitors (PPIs)
- H2 Receptor Antagonists (H2RAs)
- Anti-Helicobacter Pylori Therapy
- Mucosal Protective Agents
Fig. 1 Treatment of H. pylori infection and gastric ulcer. (Gupta A, et al., 2023)
What Can We Do?
With our rich research experience and a dedicated scientist team in the field of gastrointestinal diseases research, we can offer exclusive services for different aspects of gastric ulcer research.
Gastric Ulcer Model Development Services
Based on our professional experimental model research platform, we can provide gastric ulcer model development services for our clients. Animal species available include rats, mice, and pigs.
- Chemical-induced Gastric Ulcer Models
- Surgically-induced Gastric Ulcer Models
- Transgenic Models of Gastric Ulcer
Basic Research Services for Gastric Ulcer
There are still many unexplored areas in the specific pathogenesis of gastric ulcers. We can provide you with various basic research services related to gastric ulcer, including the identification of highly specific biomarkers, as well as the exploration of the pathophysiological mechanisms of gastric ulcer from a variety of perspectives, such as gene expression, protein expression, metabolite analysis, and intestinal microbial regulation.
Drug Development Services for Gastric Ulcer
The current treatment approach of gastric ulcers aims to relieve symptoms, promote healing, and prevent both recurrence and complications associated with the condition. We can provide you with the following drug development services for the treatment of gastric ulcers.
- We evaluate the drug's ability to inhibit H+/K+ ATPase and H2 receptors in the gastric mucosa, and assess its effectiveness in reducing gastric acid secretion and promoting ulcer healing.
- For gastric mucosal protectants and antacids, we evaluate whether the drug can neutralize gastric acid or improve the gastric mucosal barrier function.
- For anti-Helicobacter pylori drugs, we evaluate the inhibitory effect of the drug on H. pylori under in vitro and in vivo conditions.
- We also offer drug discovery services focused on gastric ulcer targets, identifying new targets or potential drug candidates based on the pathophysiological mechanisms of the condition.
Based on our professional scientist team in the field of gastrointestinal diseases research, Ace Therapeutics can develop customized project research plan according to your experimental needs. If you would like to learn more about our services, please do not hesitate to contact us.
Reference
- Gupta, A.; Shetty, S.; Mutalik, S.; et al. Treatment of H. pylori infection and gastric ulcer: Need for novel pharmaceutical formulation. Heliyon. 2023, 9(10):e20406.
Related Services
Our products and services are for research use only and can not be used for diagnostic or other purposes.
