Gestational diabetes mellitus (GDM) is a common mid- to late-term pregnancy disorder characterized by hyperglycemia, hyperinsulinemia, and impaired glucose tolerance. Gestational diabetes is thought to be multifactorial, stemming from genetic and environmental factors. High-saturated-fat diet gestational diabetes mellitus mouse models are the most widely used mouse models for studying gestational diabetes, which closely simulates metabolic abnormalities seen in human GDM.
The HFD-GDM mouse is basically generated by feeding female mouse with HFD (60% fat) for few weeks, then mating them with male mouse, and the embryonic day 0.5 was designated once the vaginal plug was present. The recommend control of HFD-GDM mouse is normal diet (10% fat) mouse.
Ace Therapeutics offers HFD-GDM mouse modeling service for GDM studying, and we also provide customized mouse model generation service for gestational diabetes study with guaranteed quality and efficiency. Just in case you couldn't find what you need, please feel free to contact us and get started with our professional one-stop service.
