Infective endocarditis is usually an infection of the endocardium due to a bacterial or fungal infection, which can cause fever, heart murmur, vascular embolism, or endocardial growths. Ace Therapeutics aims to provide clients with integrated services for basic research and drug development for infective endocarditis.
The normal heart is relatively resistant to infection. Bacteria and fungi are less likely to adhere to the surface of the endocardium, and constant blood flow helps to prevent microorganisms from colonizing endocardial structures. Thus, two factors are usually required for endocarditis. Firstly, a pre-existing abnormality of the endocardium as a causative factor, and secondly, the presence of microorganisms (e.g. Staphylococcus aureus) in the bloodstream on normal valves causing endocarditis.
Fig. 1 Risk factors involved in the onset of infective endocarditis in pregnancy. (Onofrei VA, et al., 2023)
Pathogens that cause infective endocarditis include staphylococci, enterococci, or streptococci, etc. The development of highly effective and specific drugs that inhibit and kill the pathogens that cause infections is a key direction in drug development for infections caused by different pathogens.
| Drug Name | Drug Target | Original Organization | Drug Phase |
|---|---|---|---|
| Ceftobiprole Medocaril Sodium | PBPs | Basilea Pharmaceutica AG | Approved |
| 68Ga-Edotreotide | SSTR | Advanced Accelerator Applications SA | Approved |
| Dalbavancin Hydrochloride | Peptidoglycan | Actavis | Approved |
| HMR 4004 | 50S Subunit | Sanofi | Phase 2 |
| TPH-101 | ENGASE | Telephus Medical LLC | Preclinical |
Ace Therapeutics provides clients with specialized outsourcing services for research on infective endocarditis, including disease modeling services, development of novel biomarkers and novel therapeutic agents.
Research Models
Basic Research
Drug Development
We deeply understand that the construction of infectious disease models is the foundation of infective endocarditis research, so we aim to provide professional animal model development services to meet our clients' research needs.
Animal Models of Infective Endocarditis
Endocarditis is usually an infection of the endocardium that can eventually lead to embolization of the blood vessels of the heart as well as impaired heart function. We can provide animal models of infective endocarditis disease induced by different agents.
Cardiomyocyte Cell Lines
For in vitro drug screening or pharmacodynamic studies with pathogens that induce infective endocarditis, we can provide a wide range of cardiomyocyte cell lines to support researchers' experimental needs.
There are numerous pathogens that can cause infective endocarditis, and we can provide customized basic research laboratory outsourcing services based on our clients' unique research needs to facilitate the development and advancement of basic research on infective endocarditis.
Novel Biomarkers Discovery Services
The identification of pathogenic microorganisms and their markers is a critical step for both the diagnosis of infective endocarditis and the development of therapeutic approaches. Based on our professional multi-omics technology platform, we can provide customized biomarker discovery and validation services for our clients.
Pathology and Imaging Services
For animal studies of infective endocarditis, we can provide comprehensive and professional pathology and imaging services to help researchers better develop pathogenesis and pharmacodynamic assessment.
The drug therapy strategy for infective endocarditis is generally to clarify the pathogen that triggers the infection. We can provide our clients with professional drug discovery services, customized to provide outsourcing services for the whole process of new drug discovery based on their individual drug needs.
R&D Services by Drug Type
R&D Services by Target
Ace Therapeutics has accumulated extensive knowledge in the field of infective endocarditis, which can provide our customers with basic research, biomarker development, and novel therapies discovery services. If you are interested in our services for infective endocarditis, please don't hesitate to contact us.
Ace Therapeutics offers comprehensive solutions and R&D services to researchers worldwide to advance the field of cardiovascular diseases.
We do not provide medical care for patients.
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