Infectious myocarditis is caused by viral infections in most cases, with no obvious symptoms in mild cases and severe heart failure or even sudden death in severe cases. Ace Therapeutics aims to provide comprehensive technical support and research technology services to researchers in order to promote the basic research and development of therapeutic methods for infectious myocarditis.
Infectious myocarditis is a limited or diffuse inflammatory lesion of the myocardium caused by a pathogenic infection. Among them, viral infections are the most common causes of infective myocarditis, including influenza virus, coxsackie virus, and SARS-CoV-2. The clinical symptoms of viral myocarditis vary, and in severe cases, explosive arrhythmias and heart failure, or even cardiogenic shock and sudden death may occur. Therefore, the development of efficient diagnostic tests and effective preventive and therapeutic strategies for infectious myocarditis is a top priority in infectious myocarditis research.
Fig. 1 Potential mechanisms leading to myocarditis/pericarditis following SARS-CoV-2 infection or vaccination. (Fairweather D, et al., 2023)
Currently, there are no specific drugs for myocarditis, and the pharmacologic strategy for viral myocarditis is mainly based on antiviral therapy and immunosuppressive therapy.
| Drug Name | Drug Target | Original Organization | Drug Phase |
|---|---|---|---|
| Abatacept | CD80/CD86 | Bristol Myers Squibb Co. | Approved |
| Colchicine | Tubulin | Takeda Pharmaceutical Co., Ltd. | Approved |
| CardiolRx | CB1/CB2 | Cardiol Therapeutics, Inc. | Phase 2 |
| CAN-10 | IL1RAP | University of Lund | Phase 1 |
Ace Therapeutics is committed to providing comprehensive solutions for research on infectious myocarditis, including the construction of disease models, diagnostic and examination services for animal experiments, and the development of novel therapeutic agents.
Research Models
Basic Research
Drug Development
For myocarditis research, the establishment of appropriate research models is the key to conducting research. Therefore, we offer a wide range of animal modeling services and in vitro cardiomyocyte cell lines for researchers, with the aim of advancing the science of infectious myocarditis in any way we can.
Custom Animal Models of Infectious Myocarditis
We can induce the construction of a viral myocarditis model by infecting experimental animals with Coxsackie virus by intraperitoneal injection.
Cardiomyocyte Cell Lines
For drug screening and mechanistic studies that require in vitro research, we are able to supply our customers with a variety of cardiomyocyte models to support their research needs.
Considering the high potential risk of myocarditis in clinical practice, there is an urgent need to develop rapid and effective detection and diagnostic methods. We have been focusing on biomarker research and laboratory testing and diagnostic methods for infectious myocarditis, with the hope of helping researchers to make breakthroughs in this field.
Novel Biomarkers Discovery and Identification Services
When acute myocardial infection occurs, damaged cardiomyocytes release a large number of intracellular specific proteins. Therefore, the detection of myocardium-specific damage proteins in blood as well as specific pathogens can be a key focus in the development of biomarkers and diagnostic methods.
Pathology and Imaging Services
We are able to provide outsourced research services to assist researchers with laboratory tests and examinations involved in the study of infectious myocarditis.
We provide consulting and outsourcing services for the development of infectious myocarditis drugs, and are committed to providing customized drug development solutions for our clients.
R&D Services by Drug Type
R&D Services by Target
Ace Therapeutics deeply understands the importance of infective endocarditis as the current focus of research, and we are committed to providing our clients with basic research, biomarker development, and novel therapy discovery services. If you are interested in our services for infectious myocarditis, please don't hesitate to contact us.
Ace Therapeutics offers comprehensive solutions and R&D services to researchers worldwide to advance the field of cardiovascular diseases.
We do not provide medical care for patients.
Copyright © Ace Therapeutics. All rights reserved.