High blood pressure is a common medical condition that affects the body's arteries, which is also known as hypertension. Ace Therapeutics provides integrated basic research and drug development services to help clients further explore the pathogenesis and novel therapeutic approaches to hypertension.
During the natural progression of hypertension, primary hypertension develops from incidental to definite hypertension. After a long unchanging asymptomatic period, persistent hypertension develops into complex hypertension with significant target organ damage, including the aorta and small arteries, heart, kidneys, retina, and central nervous system.
One potential mechanism by which inflammation may promote hypertension is by causing endothelial dysfunction. Endothelial dysfunction may lead to an increase in systemic vascular resistance, which can lead to the development of hypertension.
Innate and adaptive immune responses potentiate blood pressure elevation and the ensuing end-organ injury by driving reactive oxygen species (ROS) generation in cardiovascular control organs, including the vasculature, the kidney, and the nervous system.
Fig. 1 Hypertension induced cerebrovascular alterations. (Santisteban MM, et al., 2023)
The development of therapeutic drugs for hypertension has long been a hot topic in the field of cardiovascular disease research. Traditional small molecule chemical drugs occupy the majority of the hypertension drug market, but in recent years more and more drugs based on novel targets of action or novel drug types have entered the researchers' field of vision, providing more choices for the therapeutic pathway of hypertension.
Overview of Novel Drugs for Hypertension
| Drug Name | Drug Target | Original Organization | Drug Phase |
|---|---|---|---|
| Aprocitentan | ETA/ETB | Idorsia Ltd. | Approved |
| Amlodipine Benzoate | VDCCs | Azurity Pharmaceuticals, Inc. | Approved |
| Allisartan Isoproxil/Indapamide | AT1R1 | Shenzhen Salubris Pharmaceuticals Co., Ltd. | NDA |
| Valsartan/Levamlodipine | PLG | Beijing Baiao Pharmaceuticals Co., Ltd. | Phase 3 |
| Lorundrostat | ALDOS | Mitsubishi Tanabe Pharma Corp. | Phase 3 |
| REGN-5381 | NPRA | Regeneron Pharmaceuticals, Inc. | Phase 2 |
| Zilebesiran | Angiotensin | Alnylam Pharmaceuticals, Inc. | Phase 2 |
| Tonlamarsen | Angiotensin | Ionis Pharmaceuticals, Inc. | Phase 2 |
Ace Therapeutics is committed to supporting basic research and development of novel therapeutic approaches for hypertension by providing outsourced research services for disease model development and related research technology platforms.
Research Models
Basic Research
Drug Development
We are able to provide our clients with various types of animal models of hypertension, genetically engineered mouse models and cardiomyocyte cell lines to support basic and pharmaceutical research in the field of hypertension.
Custom Animal Models of Hypertension
Animal models commonly used in hypertension research include mice, rats, guinea pigs, rabbits, and dogs. We can provide customized animal models of hypertension to help our clients better conduct experimental studies related to hypertension.
Transgenic Animal Model Development Services
Hypertension is considered to be a disease that is regulated by multiple genes, and mutations in many genes may eventually trigger the development of hypertension. We can provide customized services for developing transgenic or knockout animal models, including but not limited to the following genes:
Genetically Engineered Mouse Models
We can provide the following high quality genetically engineered mice for hypertension research.
Cardiomyocyte Cell Lines
For in vitro studies, we can provide our clients with a wide range of cardiomyocyte cell lines.
With our specialized multi-omics research and pathology imaging technology platform, we are able to provide our clients with research services on the pathogenesis of hypertension, experimental animal pathology diagnosis and impact of auxiliary examination services.
Pathogenesis Research Services
The pathogenesis of hypertension is complex and is regulated by multiple genes. We are able to provide professional research services on the pathogenesis of hypertension according to the individual needs of our clients.
Pathology and Imaging Services
For animal studies of hypertension, we can provide our clients with pathology and imaging services for visual model validation and efficacy assessment, including but not limited to:
We can provide research and development services for hypertension drug therapies, including but not limited to the following drug types and targets:
R&D Services by Drug Type
R&D Services by Target
Ace Therapeutics provides our customers with basic research, biomarker development, and novel therapy discovery services based on decades of experience in the field of hypertension. If you are interested in our hypertension research services, please don't hesitate to contact us.
Ace Therapeutics offers comprehensive solutions and R&D services to researchers worldwide to advance the field of cardiovascular diseases.
We do not provide medical care for patients.
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