Stroke-Related Lipid Biomarker Development Services

Lipids have emerged as potential biomarkers for various diseases. Since lipids are structural components of cell membranes, signaling mediators, cellular barriers, and energy depots, they can reflect pathological or physiological states of metabolic disorders. In the central nervous system, lipids and lipid mediators play a key role in maintaining the structure and function of brain tissue. To a large extent, they can influence the prognosis and recovery of stroke patients. A better understanding of the functional activities of different lipid molecules provides an opportunity to understand the role of lipids in stroke pathogenesis and to identify novel lipid biomarkers and therapeutic targets.

Fig. 1. Lysophosphatidylcholines and phosphatidylcholines as biomarkers for stroke recovery. (Huang et al., 2022)

Our Services

Ace Therapeutics offers comprehensive lipid biomarker development services to help clients identify novel biomarkers that can e used to detect, diagnose, and classify stroke. Working closely with our clients, our team of experts investigates the lipids that are associated with physiological responses or the development of stroke.

Stroke-Related Lipid Biomarker Development Process

Our lipid biomarker development services include support for each step of the lipid biomarker research workflow.

Lipid biomarker discovery. We use mass spectrometry technologies for lipidomics to simultaneously detect and quantify thousands of lipids in an untargeted manner. Combined with bioinformatic analysis, we help our clients screen for potential biomarkers associated with stroke.
Lipid biomarker validation. We further validate the diagnostic and prognostic performance of lipid biomarkers in animal models or cellular assays by evaluating the sensitivity, specificity, and the area under the curve (AUC) of subjects.
Preclinical evaluation of lipid biomarkers. We help clients to investigate the role of lipid markers in the pathogenesis of stroke and validate their biological relevance. We also provide animal models of stroke to further validate the effect of lipid biomarkers.

Lipid Biomarkers We Can Develop

Low-density lipoprotein cholesterol	Triglyceride-to-high-density-lipoprotein cholesterol ratio	Oxylipin
Lipoprotein-associated phospholipase A2	Lipoprotein (a)	Apolipoprotein A-I
Apolipoprotein B	Total cholesterol	Triglycerides
High-density lipoprotein-cholesterol	Low-density lipoprotein-cholesterol	Lysophosphatidylcholines

Ace Therapeutics offers comprehensive lipid biomarker discovery and validation to help you make informed decisions in your stroke drug development. We have the experience to provide you with a full range of technical support. Please do not hesitate to contact us if you have any questions.

Reference

Huang, M., et al. (2022). Lysophosphatidylcholines and phosphatidylcholines as biomarkers for stroke recovery. Frontiers in neurology, 13, 1047101.

All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.