Stem Cells

Stem cells, also known as progenitor cells, are undifferentiated pluripotent cells with the ability to self-replicate and differentiate into different types of cells. They can self-renew and produce specific types of cells, such as muscle cells, nerve cells, heart cells, etc. Stem cells are widely used in medical research and treatment of various diseases due to their powerful regenerative capabilities.

Stem Cells for BBB Modeling

The blood-brain barrier (BBB) is a highly selective barrier that separates blood circulation from brain tissue. It plays a vital role in maintaining brain homeostasis by tightly regulating the movement of molecules, nutrients and cells between the blood and brain. Researchers create personalized BBB models by differentiating stem cells, such as induced pluripotent stem cells (iPSCs), into brain endothelial cells (BECs) to study individual differences in drug transport and disease mechanisms. In addition, researchers also use stem cells to design three-dimensional (3D) BBB models to study cell-cell interactions, barrier integrity, and drug penetration. Compared with traditional two-dimensional cell culture systems, 3D BBB models better simulate the complex structure and physiology of the BBB and can more realistically reflect the in vivo environment.

Overall, stem cells provide more possibilities for constructing BBB models, which helps researchers study the development, function, and dysfunction of the BBB in a controlled laboratory environment, thereby further elucidating neurodegenerative diseases, brain developmental disorders and potential mechanisms of drug delivery to the brain.

Ace Therapeutics provides a variety of, high-quality stem cells including iPSCs, embryonic stem cells, adult stem cells and iPSC-derived cells that can be used individually or in combination to create in vitro models of the BBB that mimic its physiological properties and functions. Our stem cells for BBB modeling are cultured and differentiation according to standardized procedures to ensure stable cell quality between different batc.

Additionally, we offer a variety of supplement media designed to balance and replenish specific cell types thus maximizing their life expectancy.

Cat.#	Name	Description	Price
BBM-C-181	Human Mesenchymal Stem Cells from Placenta (hPSCs)	Human Mesenchymal Stem Cells from Placenta (hPSCs) from Ace Therapeutics are human mesenchymal stem cells (hMSC) isolated from placental tissue, specifically from amnion, decidua, or chorion villi. MSC have been shown to differentiate in vitro into adipocytes, chondrocytes, osteoblasts, myocytes, and β-pancreatic islets cells. They can also transdifferentiate into neuronal cells and hepatocytes.	inquiry
BBM-C-182	Human Placental Derived Mesenchymal Stem Cell	Human Placental Derived Mesenchymal Stem Cell are a well-characterized population of adult stem cells. These adult stem cells have a broad therapeutic potential due to their capability to renew and differentiate into various lineages of mature cells that produce fat, cartilage, bone, tendon, and muscle when cultured under specific permissive conditions. These cells are expanded in a Mesenchymal Stem Cell Medium and then cryopreserved at passage 2. The human placental MSC express typical mesenchymal cell surface markers, such as CD105, CD73, and CD90 and are negative for hematopoietic markers including CD34, CD45, and endothelial cell marker CD31.	inquiry
BBM-C-183	Human iPSC From Adipose Mesenchymal Stromal Cells	Human iPSC From Adipose Mesenchymal Stromal Cells from Ace Therapeutics are generated using an episomal reprogramming containing a proprietary mix of vectors, containing Oct-4, Sox-2, Klf-4 along with p53 Anti-sense, EBNA-1. The cell line was validated for pluripotency based on colony morphology, alkaline phosphatase expression, and expression of SSEA-4.iPS colonies exhibit classical morphology and growth.	inquiry

All of our products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.