Stem cells, also known as progenitor cells, are undifferentiated pluripotent cells with the ability to self-replicate and differentiate into different types of cells. They can self-renew and produce specific types of cells, such as muscle cells, nerve cells, heart cells, etc. Stem cells are widely used in medical research and treatment of various diseases due to their powerful regenerative capabilities.
The blood-brain barrier (BBB) is a highly selective barrier that separates blood circulation from brain tissue. It plays a vital role in maintaining brain homeostasis by tightly regulating the movement of molecules, nutrients and cells between the blood and brain. Researchers create personalized BBB models by differentiating stem cells, such as induced pluripotent stem cells (iPSCs), into brain endothelial cells (BECs) to study individual differences in drug transport and disease mechanisms. In addition, researchers also use stem cells to design three-dimensional (3D) BBB models to study cell-cell interactions, barrier integrity, and drug penetration. Compared with traditional two-dimensional cell culture systems, 3D BBB models better simulate the complex structure and physiology of the BBB and can more realistically reflect the in vivo environment.
Overall, stem cells provide more possibilities for constructing BBB models, which helps researchers study the development, function, and dysfunction of the BBB in a controlled laboratory environment, thereby further elucidating neurodegenerative diseases, brain developmental disorders and potential mechanisms of drug delivery to the brain.
Ace Therapeutics provides a variety of, high-quality stem cells including iPSCs, embryonic stem cells, adult stem cells and iPSC-derived cells that can be used individually or in combination to create in vitro models of the BBB that mimic its physiological properties and functions. Our stem cells for BBB modeling are cultured and differentiation according to standardized procedures to ensure stable cell quality between different batc.
Additionally, we offer a variety of supplement media designed to balance and replenish specific cell types thus maximizing their life expectancy.
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Ace Therapeutics is a global leading provider of stroke research services. We are committed to accelerating progress in stroke research and drug development.