Primary Cells

Primary cells are primary cultured cells isolated from fresh living tissues, such as organs, embryos, and peripheral blood, which can maintain the basic characteristics of the original cells. With the exception of stem and progenitor cells, most primary cells are terminally differentiated cells with highly specific types and high levels of functionality. As an in vitro experimental model, primary cells have been widely used in basic research on molecules, cell biology, and biomedicine.

Primary Cells for BBB Modeling

In the context of blood-brain barrier (BBB) research, primary cells have been successfully used to model the structure and function of the BBB. The BBB is a special structure located within the walls of cerebral blood vessels that can prevent substances in the blood from entering the brain tissue to a certain extent. It is mainly composed of tightly connected cerebral vascular endothelial cells and surrounding glial cells. The physiological and pathological processes of the BBB can be better simulated and studied by using BBB models established with primary cells, , further promoting the research and treatment of blood-brain barrier-related diseases. Currently, researchers have used different types of primary cells, including endothelial cells, astrocytes and pericytes, to successfully construct blood-brain barrier models in vitro to study the BBB permeability and toxicity of drug, as well as the impact of diseases on the BBB.

Ace Therapeutics provides a variety of primary cells from humans and animals that can be used individually or in combination to create in vitro models of the BBB that mimic its physiological properties and functions. Our primary cells for BBB modeling are taken from fresh brain tissue and separated and cultured according to standardized procedures to ensure stable cell quality between different batches.

Additionally, we offer a variety of supplement media designed to balance and replenish specific cell types thus maximizing their life expectancy.