Ace Therapeutics can build animal models of SAH using the Circle of Willis at the skull base. This process involves the insertion of an endovascular filament through the external carotid artery. This model can mimic the burst of a cerebral aneurysm and most of its sequels reasonably well.
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Preclinical Subarachnoid Hemorrhage Research Services
Subarachnoid hemorrhage (SAH) is a type of stroke caused by bleeding into the space between the pia mater and the arachnoid mater. SAH is often a devastating clinical event, and the mortality rate of survivors is high, as well as the morbidity rate. Surprisingly, SAH is far less studied than other neurovascular diseases. As a result, several important aspects of the molecular and cellular pathophysiology of SAH are not well defined, which significantly hinders the development of novel therapeutic strategies. Therefore, high-quality preclinical research and therapeutic development are essential to address the challenges posed by SAH.
Fig. 1 Diffusion tensor imaging in patients with subarachnoid hemorrhage. (Jang, et al., 2022)
At Ace Therapeutics, we are leading preclinical contract research provider for SAH. Our mission is to assist clients in accelerating the development of effective therapeutics for this disease.
Custom Animal Models of Subarachnoid Hemorrhage
Ace Therapeutics is committed to enhancing the understanding of the pathogenesis and therapeutic development for SAH using specialized animal models tailored specifically for SAH research.
The Endovascular Circle of Willis Perforation Model or Filament Model
Whole Blood–induced Intracerebral Hemorrhage Model
We can induce non-aneurysmal subarachnoid hemorrhage in animals by injecting autologous or allogeneic whole blood directly into the subarachnoid space. This model allows us to help our clients monitor neurological deficits, brain imaging changes, and histopathological features in animal models of SAH before and after drug administration.
Types of Drugs We Can Develop for Subarachnoid Hemorrhage
Preclinical Evaluation of Subarachnoid Hemorrhage Therapies
We provide a comprehensive range of preclinical services to evaluate the therapeutic effects of drugs on SAH.
| Preclinical Evaluation Services | Service Details |
|---|---|
| Monitoring physiological parameters | Monitor basic physiologic parameters such as blood pressure, heart rate, respiratory rate, and body temperature to assess the effect of drugs on overall physiologic status in animal models of SAH. |
| Behavioral testing | Provide a range of neurological function scores and behavioral testing to assess whether the drugs could improve neurological function in animal models of SAH. |
| Brain imaging services | Observe the amount of bleeding in the brain and cerebral edema before and after drug administration in animal models of SAH by using imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI). |
| Histological evaluation |
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Comprehensive preclinical testing is crucial for evaluating the efficacy of SAH therapy. At Ace Therapeutics, we emphasize rigorous evaluation and validation processes to provide reliable preclinical data of your candidate drug. Contact us today to begin your journey of discovery.
References
- Bühler, D., et al. (2014). Protocol for the induction of subarachnoid hemorrhage in mice by perforation of the Circle of Willis with an endovascular filament. Translational stroke research, 5, 653-659.
- Jang, S. H., & Kwon, Y. H. (2022). Midbrain injury in patients with subarachnoid hemorrhage: a diffusion tensor imaging study. Scientific Reports, 12(1), 187.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
