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- BBB DamageCell Death and ApoptosisNeuroinflammationNeuronal Damage and RepairOxidative StressVascular Mechanisms
- 3D BBB Models
- Organ-on-a-Chip BBB ModelsTranswell Models3D BBB Models Culture Substrate
- 3D HydrogelsCollagensAnmial BBB ModelsCell Lines for BBB Modeling
- Immortalized CellsPrimary CellsStem Cells
Organ-on-a-Chip BBB Models
BBB-on-a-chip aims to recreate a functional human BBB with appropriate 3D spatial arrangement of cells, intercellular communication, and organ-specific mechanical and biochemical gradients. At Ace Therapeutics, we offer several organ-on-a-chip BBB models that provide a realistic representation of the BBB, allowing you to study drug transport across the barrier, evaluate the efficacy of drug candidates, and investigate the mechanisms of neurodegenerative diseases.
With our BBB organ-on-a-chip models, you can evaluate the permeability of drugs across the barrier, assess drug efficacy, and study the impact of various factors on the BBB function. This technology offers a more cost-effective and time-efficient alternative to traditional animal models and static cell culture systems.
What Is Organ-on-a-Chip?
An organ chip, a new type of biomedical device, is an artificial organ model developed based on microfluidic technology and biochip technology. It uses tiny chips or biological materials to build structures that simulate real organs, and studies and observes organ functions and reactions by simulating physiological functions and physiological environments. These have been used to overcome the limitations of traditional in vitro models.
Organ-on-a-Chip BBB Models
For BBB researchs, traditional in vitro models rely on Petri dishes or Transwell systems. However, these static models lack necessary microenvironmental factors such as shear stress and appropriate cell-cell interactions. Organ-on-a-chip BBB models are bioengineered devices that mimic the structure and function of the human BBB to better recreate the highly dynamic in vivo human brain microenvironment known as the neurovascular unit (NVU).
Fig. 1. 3D spheroid models of the BBB. (Cui B, et al., 2022)
Please choose from our organ-on-a-chip BBB kits to build 3D BBB or BBB-related organ disease models!
Reference- Cui B, Cho SW. Blood-brain barrier-on-a-chip for brain disease modeling and drug testing. BMB Rep. 2022, 55(5):213-219.
Cat.# Name Description Price BBM-M-007 Blood-Brain Barrier Organ-on-a-Chip Blood-Brain Barrier Organ-on-a-Chip from Ace Therapeutics is established by replicating the blood-brain barrier (BBB), which is an excellent model for studying the interactions between cells and the transmission of materials and signals between cells. This Blood-Brain Barrier Organ-on-a-Chip's peripheral chambers are used to culture the first type of cells, while the central chamber is used to culture the second type of cells. The porous structure enables communication between cells in the peripheral compartment and cells in the central compartment.inquiry BBM-M-008 High-throughput Blood-Brain Barrier Organ-on-a-Chip (IBAC MI) High-throughput Blood-Brain Barrier Organ-on-a-Chip (IBAC MI) from Ace Therapeutics is a high-throughput organ chip suitable for building the blood-brain barrier. It can not only monitor cells in real-time but also realize multi-organ co-culture.inquiry BBM-M-009 3D Blood Brain Barrier Model (TEER configuration) 3D Blood Brain Barrier Model recreates the in vivo microenvironment by mimicking the histology of brain tissue cells that communicate with BBB epithelial endothelial cells. The IMN2 TEER option allows you to accurately measure resistance, providing a non-invasive method to monitor tight junctions in real-time.inquiry BBM-M-010 3D Blood-Brain Barrier Model (IMN2 linear) 3D Blood Brain Barrier Model recreates the in vivo microenvironment by mimicking the histology of brain tissue cells that communicate with BBB epithelial endothelial cells.inquiry BBM-M-011 3D Blood-Brain Barrier Model (IMN2 radial) 3D Blood Brain Barrier Model recreates the in vivo microenvironment by mimicking the histology of brain tissue cells that communicate with BBB epithelial endothelial cells.inquiry BBM-M-012 Blood-Brain Barrier Organ Chip for Penetrance Test Blood-Brain Barrier Organ Chip for Penetrance Test from Ace Therapeutics is an organ-on-a-chip consisting of tube chambers that represent blood circulation in the brain's microcirculation, allowing assessment of whether compounds can cross the BBB.inquiry BBM-M-013 Blood-Brain Barrier Plug-and-Play Instrument Pack Blood-Brain Barrier Plug-and-Play Instrument Pack from Ace Therapeutics includes two channels, a vascular channel and a neural channel, separated by a porous membrane, simulating the BBB through dynamic culture and application of shear stress.inquiry BBM-M-014 Ready-To-Use High-Throughput Blood-Brain Barrier Organ-on-a-Chip with HBMEC Tubules Ready-to-use High-throughput Blood-Brain Barrier Organ-on-a-Chip with HBMEC Tubules from Ace Therapeutics is a microfluidic chip that provides a rapid method to access blood-brain Data related to barrier studies.inquiry All of our products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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